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Table 1 Studies empirically comparing health behavior changes among those informed of a high-risk genetic variant compared with those provided no genetic risk information*

From: Motivation in the age of genomics: why genetic findings of disease susceptibility might not motivate behavior change

Publication

Health behavior

Follow-Up period

N**

OR (95% CI)**

Overall finding

McBride 2002

Smoking Cessation

Sustained at 6 & 12 months

104 vs. 185

2.79 (1.15 – 6.78)

Positive

Ito et al. 2006

Smoking Cessation

9 months

167 vs. 356

1.78 (1.12 – 2.83)

Positive

Sanderson 2008

Smoking Cessation

2 months

20 vs. 18

1.40 (0.35 – 5.57)

Negative

Chao 2008

Diet Changes

12 months

50 vs. 51

3.33 (0.85 – 13.02)

Negative

Chao 2008

Physical Activity

12 months

50 vs. 51

1.78 (0.31 – 10.25)

Negative

Chao 2008

Medication/Vitamin Use

12 months

50 vs. 51

1.72 (0.72 – 4.13)

Negative

  1. *Some values not provided in original publication, but reported by authors to a workgroup conducting a Cochrane Collaboration review. These findings were reported in Marteau 2010.
  2. ** Elevated risk group vs. no genetic information (control) group.